Bursa Uludağ University · Our Team
Dr. Oğuzhan Akgün
Molecular Biology
Cancer research · Cellular models · Bioinformatics
About
Dr. Oğuzhan Akgün earned his bachelor's degree in Biology and his master's and doctoral degrees in Molecular Biology at Bursa Uludağ University. His research focuses on the molecular mechanisms of cancer, the efficacy of anticancer compounds, and cellular models for evaluating treatment responses.
By combining cell culture and organoid models with bioinformatic analyses, he investigates drug responses, gene and protein interactions, and potential biomarkers.
Research interests
Cancer biology and anticancer drug research
Evaluation of newly synthesized and naturally derived compounds through cell viability, cytotoxicity, and molecular mechanism analyses, with a focus on biological pathways in cancer cells.
Cell culture and organoid models
Establishment and characterization of primary cell and tissue cultures and human-derived organoid models for disease modeling, biomarker research, and drug response studies.
Bioinformatics and molecular network analysis
Analysis of RNA-seq, methylation, and other omics datasets to construct gene and protein interaction networks and identify candidate biomarkers, particularly those involved in cancer pathogenesis.
Selected research projects
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TET2 mutation and pro-angiogenic signaling
Identification of TET2 mutation-associated pro-angiogenic signaling mechanisms and evaluation of their therapeutic targetability.
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Anticancer potential of Biginelli hybrids and nanocomposites
Synthesis, characterization, and investigation of the anticancer activity of selected Biginelli hybrids and their nanocomposites. A Türkiye–Serbia bilateral cooperation project.
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Anastasis and cell migration in lung cancer
Investigation of the effect of anastasis on migration in lung cancer cells.
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The relationship between anastasis and angiogenesis
Investigation of the association between anastasis and angiogenesis in non-small cell lung cancer.
Additional project research areas
- Anti-PD-L1 resistance associated with KRAS and TP53 co-mutation and molecular biomarkers.
- Epithelial–mesenchymal transition in multiple myeloma and PI3K/AKT/mTOR-mediated autophagy in bortezomib resistance.
- PIEZO1/PIEZO2 and epithelial–mesenchymal transition in bladder tumors.
- HDAC inhibitors targeting anaerobic metabolism in colon cancer.
- Nanoparticle-embedded surfaces and tri-layered synthetic skin models for wound healing.
Selected publications
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Ceragenin-Loaded Tri-Layered Skin Substitute Composed of Natural and Synthetic Biopolymers for Burn Wound Healing
Aljayyousi N., Tamahkar Irmak E., Karaca E., Tümay Özer E., Akgün O., Arı F., Yiğit Çınar A., Bozkurt Güzel Ç., Savage P. B. and Osman B.
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Molecularly Imprinted Nanoparticle-Embedded Electrospun Mat as an Antibacterial Wound Dressing
Çerçi A., Akgün O., Karaca E., Bakhshpour-Yücel M., Arı F., Yiğit Çınar A., Bozkurt Güzel Ç. and Osman B.
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Tr-KIT Downstream Regulation by YY1 and NFYA Transcription Factors Knockdown in Prostate Cancer Cells
Ergün S., Arı F., Benli E., Altay D., Noyan T., Erdem T., Arıcı Y., Akgün O. and Aslan S.
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Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers
Ertürk E., Onur Ö. E., Akgün O., Tuna G., Yıldız Y. and Arı F.
View publication ↗
Awards
3rd International Conference on Chemo and Bioinformatics
Anti-metastatic effects of a chalcone complex on prostate cancer and prostate cancer stem cell-like cells. Kragujevac, Serbia · 22–27 September 2025.
21st Uludağ Internal Medicine Winter Congress
Evaluation of the effects of mechanosensitive ion channels on cell polarity and prognostic processes in bladder tumors. 6–9 March 2025.